Depo-Provera (medroxyprogesterone) is a form of progesterone, a female hormone that prevents ovulation (the release of an egg from an ovary). This medicine also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus. Depo Provera injections may cause a variety of side effects. Seek emergency medical help if you experience signs of an allergic reaction such as hives, itchy skin rash, difficulty breathing, or swelling of the face, tongue, or throat. Depo-Provera (medroxyprogesterone acetate) is a form of progesterone, a female hormone used as contraception to prevent pregnancy. Depo-Provera is also used to reduce pain cause by endometriosis, and to ease pain and symptoms in women with metastatic uterine or kidney cancer. Doctors give unbiased, trusted information on whether Depo Provera can cause or treat Ankle Pain: Dr. Agarwal on depo shot and leg and ankle pain: Leg weakness after epidural injections is alwasy concerning and may indicate some injury to a nerve or surrounding area. You must get this checked out with your pain doctor. It may be the that the epdidural steroids unmasked an underlying nerve. She is now on Provera 500 mg. Recently, she has developed swelling in her right arm (the opposite side of the primary cancer) and both legs/ankles/feet. Can Provera 500 mg be the possible cause of the swelling? Should she stop the tablets? Thanks. There is no Foot, leg, and ankle swelling reported by people who take Depo-provera yet. This review analyzes which people have Foot, leg, and ankle swelling with Depo-provera. It is created by eHealthMe based on reports from FDA, and is updated regularly. Along with its needed effects, medroxyprogesterone (the active ingredient contained in Depo-Provera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Summary. Swelling is found among people who take Depo-provera, especially for people who are female, 40-49 old , have been taking the drug for 1 month, also take medication Lunesta, and have Eczema.